A detour has been established for smaller vehicles but not for large trucks.
Non-truck traffic can follow the detour signs onto Hardy Road, Turner Branch Road, Goodview Road, Horseshoe Bend Road and Diamond Hill Road.
The detour is expected to remain in place for several hours. Commercial vehicles are being turned around on Route 122.
Motorists are encouraged to avoid the area and seek alternate routes.
For the latest information on this closure, visit www.511Virginia.org or follow us on twitter at @511southwestva or @VaDOTSalem.